diff --git a/.zuul.yaml b/.zuul.yaml
index 3d3287df..afe8fec3 100644
--- a/.zuul.yaml
+++ b/.zuul.yaml
@@ -27,7 +27,6 @@
       - horizon-nodejs10-jobs
       - horizon-non-primary-django-jobs
       - openstack-lower-constraints-jobs
-      - openstack-python-jobs
       - openstack-python3-ussuri-jobs
       - publish-openstack-docs-pti
       - release-notes-jobs-python3
diff --git a/doc/requirements.txt b/doc/requirements.txt
index 93bb154d..10101c2f 100644
--- a/doc/requirements.txt
+++ b/doc/requirements.txt
@@ -1,4 +1,3 @@
-sphinx!=1.6.6,!=1.6.7,>=1.6.2,<2.0.0;python_version=='2.7' # BSD
 sphinx!=1.6.6,!=1.6.7,!=2.1.0,>=1.6.2;python_version>='3.4' # BSD
 openstackdocstheme>=1.20.0 # Apache-2.0
 reno>=2.5.0 # Apache-2.0
diff --git a/ironic_ui/karma.conf.js b/ironic_ui/karma.conf.js
index 67037090..b784757d 100644
--- a/ironic_ui/karma.conf.js
+++ b/ironic_ui/karma.conf.js
@@ -17,7 +17,7 @@
 
   module.exports = function (config) {
     // This tox venv is setup in the post-install npm step
-    var toxPath = '../.tox/py27/lib/python2.7/site-packages/';
+    var toxPath = '../.tox/py36/lib/python3.6/site-packages/';
 
     config.set({
       preprocessors: {
diff --git a/manage.py b/manage.py
index b9e0f36e..1a13c6f1 100755
--- a/manage.py
+++ b/manage.py
@@ -1,4 +1,4 @@
-#!/usr/bin/env python
+#!/usr/bin/env python3
 
 # Copyright 2016 Cisco Systems, Inc.
 #
diff --git a/package.json b/package.json
index 4926a0cd..0e45a548 100644
--- a/package.json
+++ b/package.json
@@ -24,7 +24,7 @@
     "karma-threshold-reporter": "^0.1.15"
   },
   "scripts": {
-    "postinstall": "if [ ! -d .tox ] || [ ! -d .tox/py27 ]; then tox -epy27 --notest; fi",
+    "postinstall": "if [ ! -d .tox ] || [ ! -d .tox/py36 ]; then tox -epy36 --notest; fi",
     "test": "karma start ironic_ui/karma.conf.js --single-run",
     "lint": "eslint --no-color ironic_ui/static",
     "lintq": "eslint --quiet ironic_ui/static"
diff --git a/releasenotes/notes/drop-python2-0bf548c3946068af.yaml b/releasenotes/notes/drop-python2-0bf548c3946068af.yaml
new file mode 100644
index 00000000..065dcf16
--- /dev/null
+++ b/releasenotes/notes/drop-python2-0bf548c3946068af.yaml
@@ -0,0 +1,6 @@
+---
+upgrade:
+  - |
+    Python 2.7 support has been dropped. Last release of ironic-ui to
+    support Python 2.7 is OpenStack Train. The minimum version of Python
+    now supported by ironic-ui is Python 3.6.
diff --git a/setup.cfg b/setup.cfg
index a9a70ae8..fa07fa33 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -13,8 +13,6 @@ classifier =
     License :: OSI Approved :: Apache Software License
     Operating System :: POSIX :: Linux
     Programming Language :: Python
-    Programming Language :: Python :: 2
-    Programming Language :: Python :: 2.7
     Programming Language :: Python :: 3
     Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
diff --git a/tox.ini b/tox.ini
index b115f591..f17ccab2 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,11 +1,12 @@
 [tox]
 minversion = 1.8
 skipsdist = True
-envlist = py3,py27,py3-{dj111,dj22},pep8
+envlist = py3,py3-{dj111,dj22},pep8
 
 [testenv]
 usedevelop = True
 install_command = pip install -c{env:UPPER_CONSTRAINTS_FILE:https://releases.openstack.org/constraints/upper/master} {opts} {packages}
+basepython = python3
 setenv = VIRTUAL_ENV={envdir}
          NOSE_WITH_OPENSTACK=1
          NOSE_OPENSTACK_COLOR=1
@@ -28,30 +29,24 @@ setenv =
   INTEGRATION_TESTS=1
   SELENIUM_HEADLESS=1
   HORIZON_INTEGRATION_TESTS_CONFIG_FILE=ironic_ui/test/integration/horizon.conf
-basepython = python3
 commands = python manage.py test ironic_ui.test.integration --settings=ironic_ui.test.settings --tag integration
 
 
 [testenv:pep8]
-basepython = python3
 commands = flake8 {posargs}
 
 [testenv:venv]
-basepython = python3
 commands = {posargs}
 
 [testenv:py3-dev]
-basepython = python3
 commands =
   pip install {env:HORIZON_REPO:git+https://opendev.org/openstack/horizon}
   {[testenv]commands}
 
 [testenv:cover]
-basepython = python3
 commands = python setup.py test --coverage --testr-args='{posargs}'
 
 [testenv:docs]
-basepython = python3
 deps =
   -c{env:UPPER_CONSTRAINTS_FILE:https://releases.openstack.org/constraints/upper/master}
   -r{toxinidir}/doc/requirements.txt
@@ -59,7 +54,6 @@ commands =
   sphinx-build -W -b html doc/source doc/build/html
 
 [testenv:pdf-docs]
-basepython = python3
 deps = {[testenv:docs]deps}
 whitelist_externals = make
 commands =
@@ -67,7 +61,6 @@ commands =
   make -C doc/build/pdf
 
 [testenv:debug]
-basepython = python3
 commands = oslo_debug_helper -t ironic_ui/test/tests {posargs}
 
 [flake8]
@@ -77,14 +70,12 @@ builtins = _
 exclude=.venv,.git,.tox,dist,doc,*lib/python*,*egg,build
 
 [testenv:releasenotes]
-basepython = python3
 deps =
   -c{env:UPPER_CONSTRAINTS_FILE:https://releases.openstack.org/constraints/upper/master}
   -r{toxinidir}/doc/requirements.txt
 commands = sphinx-build -a -W -E -d releasenotes/build/doctrees -b html releasenotes/source releasenotes/build/html
 
 [testenv:extractmessages]
-basepython = python3
 commands =
   pybabel extract -F babel-django.cfg \
     -o ironic_ui/locale/django.pot -k gettext_noop -k gettext_lazy -k ngettext_lazy:1,2 \
@@ -98,7 +89,6 @@ commands =
 
 
 [testenv:lower-constraints]
-basepython = python3
 deps =
   -c{toxinidir}/lower-constraints.txt
   -r{toxinidir}/test-requirements.txt