diff --git a/octavia/amphorae/backends/agent/api_server/server.py b/octavia/amphorae/backends/agent/api_server/server.py
index 7daa82d1cc..b46eabe3ee 100644
--- a/octavia/amphorae/backends/agent/api_server/server.py
+++ b/octavia/amphorae/backends/agent/api_server/server.py
@@ -56,7 +56,7 @@ def register_app_error_handler(app):
 
 
 class Server:
-    def __init__(self):
+    def __init__(self, hm_queue):
         self.app = flask.Flask(__name__)
         self._osutils = osutils.BaseOS.get_os_util()
         self._keepalived = keepalived.Keepalived()
@@ -64,6 +64,7 @@ class Server:
         self._lvs_listener = keepalivedlvs.KeepalivedLvs()
         self._plug = plug.Plug(self._osutils)
         self._amphora_info = amphora_info.AmphoraInfo(self._osutils)
+        self._hm_queue = hm_queue
 
         register_app_error_handler(self.app)
 
@@ -253,6 +254,8 @@ class Server:
                     b = stream.read(BUFFER)
 
             CONF.mutate_config_files()
+            # Signal to the health manager process to reload it's configuration
+            self._hm_queue.put('reload')
         except Exception as e:
             LOG.error("Unable to update amphora-agent configuration: %s",
                       str(e))
diff --git a/octavia/cmd/agent.py b/octavia/cmd/agent.py
index 636c5f1aaf..6475e65229 100644
--- a/octavia/cmd/agent.py
+++ b/octavia/cmd/agent.py
@@ -31,7 +31,6 @@ from octavia import version
 
 
 CONF = cfg.CONF
-HM_SENDER_CMD_QUEUE = multiproc.Queue()
 
 
 class AmphoraAgent(gunicorn.app.base.BaseApplication):
@@ -58,14 +57,19 @@ def main():
     gmr_opts.set_defaults(CONF)
     gmr.TextGuruMeditation.setup_autorun(version, conf=CONF)
 
+    # Setup a multiprocessing manager and queue to share between the
+    # health manager sender and the workers. This allows us to reload the
+    # configuration into the health manager sender process.
+    hm_queue = multiproc.Manager().Queue()
+
     health_sender_proc = multiproc.Process(name='HM_sender',
                                            target=health_daemon.run_sender,
-                                           args=(HM_SENDER_CMD_QUEUE,))
+                                           args=(hm_queue,))
     health_sender_proc.daemon = True
     health_sender_proc.start()
 
     # Initiate server class
-    server_instance = server.Server()
+    server_instance = server.Server(hm_queue)
 
     bind_ip_port = utils.ip_port_str(CONF.haproxy_amphora.bind_host,
                                      CONF.haproxy_amphora.bind_port)
diff --git a/octavia/tests/functional/amphorae/backend/agent/api_server/test_server.py b/octavia/tests/functional/amphorae/backend/agent/api_server/test_server.py
index a0c48bf72b..f2d8f0c515 100644
--- a/octavia/tests/functional/amphorae/backend/agent/api_server/test_server.py
+++ b/octavia/tests/functional/amphorae/backend/agent/api_server/test_server.py
@@ -57,16 +57,17 @@ class TestServerTestCase(base.TestCase):
         self.useFixture(fixtures.MockPatch(
             'oslo_config.cfg.find_config_files',
             return_value=[AMP_AGENT_CONF_PATH]))
+        hm_queue = mock.MagicMock()
         with mock.patch('distro.id', return_value='ubuntu'), mock.patch(
                 'octavia.amphorae.backends.agent.api_server.plug.'
                 'Plug.plug_lo'):
-            self.ubuntu_test_server = server.Server()
+            self.ubuntu_test_server = server.Server(hm_queue)
             self.ubuntu_app = self.ubuntu_test_server.app.test_client()
 
         with mock.patch('distro.id', return_value='centos'), mock.patch(
                 'octavia.amphorae.backends.agent.api_server.plug.'
                 'Plug.plug_lo'):
-            self.centos_test_server = server.Server()
+            self.centos_test_server = server.Server(hm_queue)
             self.centos_app = self.centos_test_server.app.test_client()
 
     def test_ubuntu_haproxy(self):
@@ -2887,10 +2888,11 @@ class TestServerTestCase(base.TestCase):
             self.assertEqual(500, rv.status_code)
 
     def test_version_discovery(self):
+        hm_queue = mock.MagicMock()
         with mock.patch('distro.id', return_value='ubuntu'), mock.patch(
                 'octavia.amphorae.backends.agent.api_server.plug.'
                 'Plug.plug_lo'):
-            self.test_client = server.Server().app.test_client()
+            self.test_client = server.Server(hm_queue).app.test_client()
         expected_dict = {'api_version': api_server.VERSION}
         rv = self.test_client.get('/')
         self.assertEqual(200, rv.status_code)
diff --git a/releasenotes/notes/Fix-Amphora-Config-Update-06b649883c7a4f44.yaml b/releasenotes/notes/Fix-Amphora-Config-Update-06b649883c7a4f44.yaml
new file mode 100644
index 0000000000..80b637b5b5
--- /dev/null
+++ b/releasenotes/notes/Fix-Amphora-Config-Update-06b649883c7a4f44.yaml
@@ -0,0 +1,6 @@
+---
+fixes:
+  - |
+    Fixed a bug where the Amphora configuration update would only update the
+    Amphora agent configuration, but the health sender would not be updated
+    with the new controller IP list.